Table 2. Blood plasma concentrations of putative AD biomarker targets as measured by immunoassay.

Molecule	Healthy Cohort			AD Cohort
	Concentration	Correlation with age		Concentration	Correlation with age
		Correlation coefficient (r)	p-value		Correlation coefficient (r)	p-value
Aβ42	6.49 ± 1.25 pmol/L	0.0755	0.6432	6.32 ± 1.74 pmol/L	0.3802	0.0185*
ApoE	4776 ± 3238 ng/ml	−0.3833	0.0025**	4607 ± 2689 ng/ml	0.1369	0.3056
Clusterin	2534 ± 1397 ng/ml	−0.2536	0.0505	2516 ± 1336 ng/ml	0.0824	0.5386
Fibrinogen	49.59 ± 20.72 μg/ml	0.0570	0.6652	41.57 ± 21.72 μg/ml	0.2234	0.0918
Keratin 9	34.7 ± 47.6 pg/ml	−0.2316	0.0750	64.4 ± 88.0 pg/ml	0.1646	0.2168
SPARCL1	1126 ± 533 ng/ml	0.4619	0.0002***	1204 ± 757 ng/ml	0.1711	0.1992
Tau	43.90 ± 13.78 ng/ml	−0.4082	0.0012**	43.10 ± 14.84 ng/ml	0.1062	0.4275

Spearman correlation coefficients for protein concentration and patient age were determined using GraphPad Prism Version 5.02. A p-value ≤ 0.05 was considered statistically significant.