Table 3. Correlations between protein concentrations of Keratin 9 and other AD-associated molecules in blood plasma samples.
| Molecule 1 | Molecule 2 | Healthy Cohort |
AD Cohort |
||
|---|---|---|---|---|---|
| Spearman correlation coefficient (r) | p-value | Spearman correlation coefficient (r) | p-value | ||
| Keratin 9 | Aβ42 | 0.1045 | p = 0.5209 | −0.05246 | p = 0.7478 |
| Keratin 9 | ApoE | 0.3829 | p = 0.0025** | 0.6380 | p < 0.0001**** |
| Keratin 9 | Clusterin | 0.2707 | p = 0.0364* | 0.5276 | p < 0.0001**** |
| Keratin 9 | Fibrinogen | 0.1107 | p = 0.3998 | 0.03512 | p = 0.7899 |
| Keratin 9 | SPARCL1 | −0.3026 | p = 0.0188* | −0.3102 | p = 0.0158* |
| Keratin 9 | Tau | 0.4338 | p = 0.0005*** | 0.6256 | p < 0.0001**** |
Protein concentrations were determined using the appropriate ELISA of Luminex assay. Spearman correlation coefficients were determined for all protein pairings in healthy and AD patient cohorts using GraphPad Prism Version 5.02. A p-value ≤ 0.05 was considered statistically significant.