Table 4. Components of the Keratin 9 interactome determined using VisANT software.
| KRT9 interacting partner | Experimental Evidence of Interaction | Reference | Direct Link to AMA Interactome |
||
|---|---|---|---|---|---|
| APP | APOE | MAPT | |||
| ADAM metallopeptidase domain 3B (ADAM3B) | Two-hybrid Test | 72 | — | — | — |
| Adrenoceptor beta 2, surface (ADRB2) | Affinity Capture-MS | 73 | — | — | — |
| Albumin (ALB) | Affinity Capture-MS; Anti-Bait Coimmunoprecipitation | 41 | ✓ | ✓ | — |
| Adaptor-related protein complex 2, mu 1 subunit (AP2M1) | Affinity Capture-MS | 67 | — | — | — |
| Adenomatous polyposis coli (APC) | Surface Plasmon Resonance | 74 | — | — | — |
| Apolipoprotein A-I (APOA1) | Affinity Capture-MS; Anti-Bait Coimmunoprecipitation | 41 | ✓ | — | — |
| Cullin-associated and neddylation-dissociated 1 (CAND1) | Affinity Capture-MS | 66 | — | — | — |
| Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL) | Affinity Capture-MS | 67 | — | — | — |
| Cadherin 1, type 1, E-cadherin (epithelial) (CDH1) | Affinity Capture-MS; Surface Plasmon Resonance | 74 | — | — | — |
| Cystic fibrosis transmembrane conductance regulator (CFTR) | Anti-Bait Coimmunoprecipitation | 75 | — | — | — |
| COP9 signalosome subunit 5 (COPS5) | Affinity Capture-MS | 66 | ✓ | — | — |
| COP9 signalosome subunit 6 (COPS6) | Affinity Capture-MS | 66 | — | — | — |
| V-crk avian sarcoma virus CT10 oncogene homolog (CRK) | Affinity Capture-MS | 67 | — | — | — |
| Cullin 1 (CUL1) | Affinity Capture-MS | 66 | — | — | — |
| Cullin 2 (CUL2) | Affinity Capture-MS | 66 | — | — | — |
| Cullin 3 (CUL3) | Affinity Capture-MS | 66 | ✓ | — | — |
| Cullin 4A (CUL4A) | Affinity Capture-MS | 66 | — | — | — |
| Cullin 4B (CUL4B) | Affinity Capture-MS | 66 | ✓ | — | — |
| Cullin 5 (CUL5) | Affinity Capture-MS | 66 | — | — | — |
| DCN1, defective in cullin neddylation 1, domain containing 1 (DCUN1D) | Affinity Capture-MS | 66 | — | — | — |
| E2F transcription factor 3 (E2F3) | Pull Down | 76 | — | — | — |
| Eukaryotic translation initiation factor 4A3 (EIF4A3) | Affinity Capture-MS | 77 | — | — | — |
| Epidermal growth factor receptor pathway substrate 15 (EPS15) | Affinity Capture-MS; Anti-Tag Coimmunoprecipitation | 67 | — | — | — |
| Fibronectin 1 (FN1) | Affinity Capture-MS | 78 | — | — | — |
| GABA(A) receptor-associated protein (GABARAP) | Anti-Tag Coimmunoprecipitation | 79 | — | — | — |
| GABA(A) receptor-associated protein like 1 (GABARAPL1) | Anti-Tag Coimmunoprecipitation | 79 | — | — | — |
| GABA(A) receptor-associated protein like 2 (GABARAPL2) | Anti-Tag Coimmunoprecipitation | 79 | ✓ | — | — |
| Growth factor receptor-bound protein 2 (GRB2) | Affinity Capture-MS | 67 | ✓ | — | — |
| Immunoglobulin heavy constant alpha 1 (IGHA1) | Anti-Bait Coimmunoprecipitation | 41 | — | — | — |
| Immunoglobulin heavy constant gamma 1 (IGHG1) | Anti-Bait Coimmunoprecipitation | 41 | — | — | — |
| Immunoglobulin heavy constant mu (IGHM) | Anti-Bait Coimmunoprecipitation | 41 | ✓ | — | — |
| Inositol polyphosphate phosphatase-like 1 (INPPL1) | Affinity Capture-MS | 67 | — | — | — |
| IQ motif containing B1 (IQCB1) | Affinity Capture-MS | 39 | — | — | — |
| Integrin, alpha 4 (ITGA4) | Affinity Capture-MS | 80 | — | — | — |
| Keratin 1 (KRT1) | Co-Fractionation | 81 | — | — | — |
| Leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) | Affinity Capture-MS | 82 | — | — | — |
| Mago-nashi homolog, proliferation-associated (MAGOH) | Affinity Capture-MS | 77 | — | — | — |
| Microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A) | Anti-Tag Coimmunoprecipitation | 79 | ✓ | — | — |
| Microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) | Anti-Tag Coimmunoprecipitation | 79 | — | — | — |
| MDM2 proto-oncogene, E3 ubiquitin protein ligase (MDM2) | Affinity Capture-MS | 69 | ✓ | — | — |
| Neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) | Affinity Capture-MS | 66 | ✓ | — | — |
| Phosphoinositide-3-kinase, regulatory subunit 2 (beta) (PIK3R2) | Affinity Capture-MS | 67 | ✓ | — | — |
| POU class 5 homeobox 1 (POU5F1) | Affinity Capture-MS | 83 | — | — | — |
| Protein phosphatase 2, regulatory subunit B, beta (PPP2R2B) | Pull Down; Anti-Tag Coimmunopreciptation | 84 | — | — | — |
| SH3-domain GRB2-like 3 (SH3GL3) | Two Hybrid Test | 72 | — | — | — |
| Src homology 2 domain containing transforming protein 1 (SHC1) | Affinity Capture-MS | 67 | ✓ | — | — |
| TRAF family member-associated NFKB activator (TANK) | Functional Linkage Network; Anti-Tag Coimmunoprecipitation | 85 | ✓ | — | — |
| TNF receptor-associated factor 3 interacting protein 1 (TRAF3IP1) | Anti-Bait Coimmunoprecipitation; Affinity Capture-MS | 86 | ✓ | — | — |
| Ubiquitin associated and SH3 domain containing B (UBASH3B) | Affinity Capture-MS | 67 | — | — | — |
| Ubiquitin C (UBC) | Affinity Capture-MS | 68 | ✓ | ✓ | ✓ |
| Ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) | Affinity Capture-MS | 87 | ✓ | — | — |
| PAN2 poly (A) specific ribonuclease subunit (USP52) | Affinity Capture-MS | 88 | — | — | — |
| Vascular cell adhesion molecule 1 (VCAM1) | Cross-linking Studies; Affinity Capture-MS | 78,80 | — | ✓ | — |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta (YWHAQ) | In vivo; Coimmunoprecipitation; Affinity Capture-MS | 89 | — | — | ✓ |
The means of determining their interaction with Keratin 9 and their links to the AMA Interactome are displayed.