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(A) Immunoblot analysis of CDK8 knockout and CDK/CDK19 double knockout cells. Three independent clones of each mutant are shown. (B) Pharmacological inhibition of CDK8 kinase activity reduces STAT1 Ser727 phosphorylation following stimulation with IFNγ. Cells were treated for 24 h in the presence or absence of 2 μM 32. (C) Cell viability in the presence of 32 at 72 h.
