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. 2016 Jan 6;7(3):223–228. doi: 10.1021/acsmedchemlett.5b00278

Table 5. Antiproliferative Activity of Compounds 13, 31, and 32 on HCT-116 Cellsa.

  HCT116 EC50 10% FBS (μM) HCT116 EC50 0.625% FBS (μM)
13 >10 8.8
31 >10 8.7
32 6.7 5.4
flavopiridol 0.034 0.059
a

Compounds 5-8, 11, and 25 were also evaluated, but had EC50 values >10 μM under both high and low serum conditions.