Table 1. Brain, Plasma Concentration, and Brain/Plasma Ratio of 26a.
dose (mg/kg) | plasma conc (nM) (SD) | brain conc (nM) (SD) | brain/plasma |
---|---|---|---|
1 | 150 (65) | 67 (46) | 0.44 (0.14) |
3 | 360 (75) | 160 (30) | 0.46 (0.10) |
10 | 1500 (320) | 420 (190) | 0.30 (0.10) |
Compound dosed PO to female rats in PEG-400/EtOH/Tween 80 (84:15:1); plasma and brain collected 5 h postdose (5 rats/dose) for determination of exposure and brain Aβ levels. Data are mean values (n = 5) with SD in parentheses.