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. 2016 Jan 11;7(3):271–276. doi: 10.1021/acsmedchemlett.5b00432

Table 1. Brain, Plasma Concentration, and Brain/Plasma Ratio of 26a.

dose (mg/kg) plasma conc (nM) (SD) brain conc (nM) (SD) brain/plasma
1 150 (65) 67 (46) 0.44 (0.14)
3 360 (75) 160 (30) 0.46 (0.10)
10 1500 (320) 420 (190) 0.30 (0.10)
a

Compound dosed PO to female rats in PEG-400/EtOH/Tween 80 (84:15:1); plasma and brain collected 5 h postdose (5 rats/dose) for determination of exposure and brain Aβ levels. Data are mean values (n = 5) with SD in parentheses.