Table 2. Anti-HIV Activity of Compound 7c against Pseudotype Viruses^a.

virus	subtypes (clades)	EC50 (μM)
CE1176	C	2.2 ± 0.64
CNE55	CRF01_AE	4.3 ± 1.1
CE0217	C	1.4 ± 0.43
X1632	G	2.5 ± 0.55
BJOX2000	CRF07_BC	2.8 ± 0.96
25710	C	2.1 ± 0.81
TRO11	B	1.6 ± 0.45
CH119	CRF07_BC	0.9 ± 0.36

^aThe antiviral activity of compound 7c was determined using a TZM-bl assay as previously described.¹⁴ Compound 7c was not toxic to TZM-bl cells at the highest tested concentration (20 μM). EC₅₀ is the concentration that inhibited the pseudotype virus infection of TZM-bl cells by 50%.¹⁸ The data in the table represent mean ± SD of three independent experiments.