. 2016 Jan 19;7(3):277–282. doi: 10.1021/acsmedchemlett.5b00447

Table 2. SAR for the Optimization of the C-Ring.

cmpd	hNa_V1.7 IC₅₀ [nM]^a	cmpd	hNa_V1.7 IC₅₀ [nM]^a
3	0.4 ± 0.2	20	51 ± 11
18	3.0 ± 0.8	21	241 ± 122
19	1.7 ± 0.4

IC₅₀ values are reported as mean ± SD, generated on an automated voltage-clamp platform.