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Effect of CypD inhibitor C-9 and CsA on Aβ-induced reduction in CcO activity. SK-N-SH cells were treated with 5 μM oligomer Aβ plus: vehicle without inhibitor, C-9 at the indicated concentrations (10 and 20 μM), CsA (1 μM), and Aβ alone (5 μM), respectively. After 48 h, CcO activity was determined in cell lysates. *P < 0.01: Aβ vs 10 μM C-9 + Aβ, 20 μM C-9 + Aβ, and CsA + Aβ, respectively.
