Table 2.

Examples of Genetically Engineered Animal Models

Organ Site	Species	Genetic Modification	Endpoint Measured	Reference
Colon	Mouse	Min (AKR mutant)	Adenoma, adenocarcinoma	[43]
Lung	Mouse	EGFR(L858R)	Adenocarcinoma	[52]
	Mouse	p53(Ala135Val), p16+/−, Kras+/−	Adenocarcinoma	Unpublished Data
Mammary	Mouse	BRCA1 and TP53 mutant	Tumor	[53]
Ovary	Mouse	Pax8-Cre Brca, Tp53, Pten mutated	Serous carcinoma	[54]
Pancreas	Mouse	hMuc1(insertion) and KrasG12D/+	Adenocarcinoma	[55]
	Mouse	KrasG12D/+	Adenocarcinoma	[56]