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. 2016 Mar 14;6:23035. doi: 10.1038/srep23035

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Copyright © 2016, Macmillan Publishers Limited

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(A) Gene set-level ER-modulated interaction between the TGFβ response gene set and the NFκB target gene set. The two gene sets, representing activities of TGFβ and NFκB proteins, were significantly correlated with each other in an ER+ dependent manner. (B) Gene-level ER+ dependent interaction among genes belonging to the two gene sets. Node size is proportional to the connectivity and nodes with connectivity ≥20 are labeled with gene symbols. Overrepresentation of inter-gene-set ER-MRTPs was observed (observed-to-expected ratio = 1.82).