Table 1.
Clinicopathologic characteristics of patients with adrenocortical carcinoma and Beclin-1 expression
| Characteristics | Patients, n (%) | Beclin-1 expression
|
P-value | |
|---|---|---|---|---|
| Positive | Negative | |||
| Age (range), years | 0.296 | |||
| <60 (32–59) | 21 (60.0) | 11 | 10 | |
| ≥60 (60–74) | 14 (40.0) | 4 | 10 | |
| Sex | 0.596 | |||
| Female | 19 (54.3) | 8 | 11 | |
| Male | 16 (45.7) | 7 | 9 | |
| Clinical stage | 0.032 | |||
| I–II | 13 (37.1) | 9 | 4 | |
| III–IV | 22 (62.9) | 6 | 16 | |
| Tumor stage | 0.019 | |||
| T1–T2 | 15 (42.9) | 10 | 5 | |
| T3–T4 | 20 (57.1) | 5 | 15 | |
| Node metastasis | 0.007 | |||
| N0 | 21 (60.0) | 13 | 8 | |
| N1 | 14 (40.4) | 2 | 12 | |
| Differentiation | 0.018 | |||
| Well–moderate | 17 (48.6) | 11 | 6 | |
| Poor | 18 (51.4) | 4 | 14 | |
Notes: Negative expression of Beclin-1 was significantly correlated with advanced stage, regional lymph node metastasis, increasing tumor stage, and poor differentiation. Categorical data are expressed as the counts (percentages). The relationships between categorical data were analyzed by the chi-square test or Fisher’s exact test.