Table 1.

Summary of the CROSS phase III trial

Parameter	41.4 Gy and paclitaxel/carboplatin followed by surgery	Surgery alone	p-value
Number (Adeno/SCC)	178 (134/41)	188 (141/43)	59
Complete resection R0, %	92	69	<0.001
pCR, %	29	-
ypN+, %	31	75	<0.001
Postoperative complications
Pulmonary	46	44
Anastomotic leakage	22	30
Death, in hospital, 30 days, %	4/2	4/3
OS, months, median	49.4	24	0.003

Adeno = Adenocarcinoma; SCC = squamous cell carcinoma; pCR = pathological complete response; OS = overall survival.