Table 4.

Comparison of definitive chemoradiotherapy versus neoadjuvant treatment followed by surgery or surgery alone

Clinical study	Histology	Stadium	Patients, n	Treatment	R0, %	Survival, months	2-year survival	3-year survival	p
Bedenne et al., 1993/2000	SCC	T1–3	129	cisplatin, 5-FU, 46 Gy + esophagectomy	75	18	34	-	NS
		N0–1
		M0	130	cisplatin, 5-FU, 66 Gy	-	19	40	-	-
Stahl et al., 1994/2002	SCC	T3–4	86	cisplatin, 5-FU, leucovorin, etoposide, 40 Gy + esophagectomy	82	16	40	31	NS
		N0–1
		M0
			86	cisplatin, 5-FU, leucovorin, etoposide, 65 Gy	-	15	35	24	NS
Chiu et al., 2000/2004	SCC	T2–3	45	esophagectomy		24	55	-	NS
		N1
		M0	36	cisplatin, 5-FU, 50–60 Gy		21	58	-

Adeno = Adenocarcinoma; SCC = squamous cell carcinoma; 5-FU = 5-fluorouracil. Only published articles were included.