Table 2.
Reduced models for predictors of age related change in cognition
| 1999 IDs | Model 1 |
Model 2 (adjusting for email status in 2011) |
Model 3 (adjusting for frailty index in 2007) |
Model 4 (adjusting for telomere length ~2000) |
||||
|---|---|---|---|---|---|---|---|---|
| β | p | β | p | β | p | β | p | |
| Age | –0.058 | <0.001 | –0.057 | <0.001 | –0.054 | <0.001 | –0.058 | <0.001 |
| Adult ability | 0.110 | 0.074 | 0.102 | 0.108 | 0.103 | 0.087 | 0.101 | 0.114 |
| Percent dietary saturated fat | −0.104 | 0.063 | −0.102 | 0.068 | −0.099 | 0.075 | −0.103 | 0.083 |
| Leg extensor power | 0.191 | <0.001 | 0.186 | 0.001 | 0.178 | 0.001 | 0.180 | 0.002 |
| Physical activity | 0.109 | 0.043 | 0.109 | 0.045 | 0.098 | 0.071 | 0.107 | 0.047 |
| Systolic blood pressure | −0.124 | 0.015 | −0.121 | 0.015 | −0.102 | 0.034 | −0.114 | 0.025 |
| Glucose level | –0.190 | <0.016 | –0.192 | <0.015 | –0.193 | <0.016 | –0.174 | <0.024 |
| Diabetes status | –1.81 | 0.002 | –1.81 | 0.002 | –1.77 | 0.003 | –1.69 | 0.003 |
| Email status (2011) | – | – | 0.069 | 0.557 | – | – | – | – |
| Frailty index (2007) | – | – | – | – | −0.104 | 0.098 | – | – |
| WC telomere length (qPCR) | 0.053 | 0.502 | ||||||
Age-related change was modelled using the ARC factor (first factor of change in 7 computerised neuropsychometric tests from the CANTAB battery, over 10 years). Reduced models contain only factors reaching a nominal p < 0.10). Missing values were imputed using multiple imputation. The ßs are all standardised, except in the cases of age and diabetes (dummy variable diabetic = 1, non-diabetic = 0). Text in bold indicates factors significant with Bonferroni correction. Where findings were in the opposite direction to expected, they are in italics. WC = White cell.