Table 1.

Positive phase III trials of cytotoxic agents in second line metastatic cancers

Ref.	Patients/phase	Treatment	Indication	Results (PFS/OS/RR) (mo)
Ford et al[18], 2014	168/III	Docetaxel	Advanced, gastric cancer that had progressed on or within 6 mo of treatment with a platinum-fluoropyrimidine combination	OS: 5.2
COUGAR-02		Active symptom control		OS: 3.6
Kang et al[28], 2012[28]	202/III	Docetaxel	Advanced gastric cancer with one or two prior chemotherapy regimens involving both fluoropyrimidines and platinum	5.2
		Irinotecan		6.5
		BSC		3.8