Table 1.
Epidemiological and clinical profiles of patients included in the transversal study n (%)
| HBV | HBV + HIV | HBV + HDV | HBV + HDV + HIV | |
| (n = 27) | (n = 22) | (n = 31) | (n = 37) | |
| Age (yr)1 | 38.54 ± 12.22 | 47.33 ± 8.50 | 41.15 ± 9.33 | 42.32 ± 7.76 |
| Gender (M/F) | 21/6 | 12/10 | 22/9 | 17/20 |
| Caucasian | 18 (67) | 20 (91) | 27 (87) | 33 (89) |
| Subsaharian | 9 (33) | 2 (9) | 4 (13) | 4 (11) |
| ALT (IU/mL)1 | 66.58 ± 76.03c | 70.67 ± 18.58 | 112.92 ± 84.39d | 90.40 ± 21.92 |
| AST (IU/mL)1 | 42.65 ± 27.76 | 32.67 ± 19.40 | 89.77 ± 62.43 | 38.33 ± 20.12 |
| Anti-HCV | 4 (15) | 2 (9) | 2 (6) | 3 (8) |
| Anti-HBe | 23 (85) | 17 (77) | 29 (93) | 31 (84) |
| HBeAg | 4 (15) | 5 (23) | 2 (7) | 6 (16) |
| HBV genotype-A | 17 (63) | 12 (54) | 12 (42) | 16 (43) |
| HBV genotype-D | 10 (37) | 10 (46) | 13 (42) | 20 (54) |
| HBV genotype-E | 0 | 0 | 4 (9) | 1 (3) |
| HBV-DNA (Log10 IU/mL)2 | 3.90 (3.15-5.85)e | 6.97 (5.58-7.25)f | 1.58 (1.00-2.43)g | 2.80 (1.00-7.02) |
| HBsAg (Log10 IU/mL)2 | 4.00 (3.81-4.22)h | 5.46 (4.15-5.61)i | 3.83 (3.59-4.39)j | 3.83 (3.24-4.38)k |
| HDV-RNA (Log10 copies/mL)2 | NA | NA | 5.20 (4.37-5.74) | 6.89 (4.41-7.73) |
Data expressed as Mean ± SD;
Data expressed as Median (IQR); c vs d: P = 0.043; e vs f: P = 0.007; f vs g: P = 0.037; h vs i: P = 0.001; j vs i and i vs k: P < 0.001. HBV genotypes data reported in this table has been obtained by commercial LIPA assay or using, in the negative cases, the PCR/sequencing method developed in this work. In two patients with CHD/HIV negative, the HBV genotype was not determined. HDV genotype 1 was found in the 60 Caucasian patients and in 6/8 (75%) of the immigrant Subsaharian patients. In the remaining 2 patients, HDV genotypes 3 and 4 were respectively detected, one of them infected with HBV-A and the other with HBV-D. In only 25 (37%) patients data about HBV/HDV coinfection date were available. No differences in the HBV duration of infection were observed between patients infected with HBV-A or HBV-D (mean ± SD: 21.5 ± 5.3 vs 23.75 ± 6.2 yr, respectively). HBV: Hepatitis B virus; HDV: Hepatitis delta virus; HIV: Human immunodeficiency virus; CHD: Chronic hepatitis delta; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.