Table 3.
Hepatitis B virus serological profile of patients
|
Serum HBV-DNA |
HBsAg |
||||||
| Genotype1 | Anti-HBe | Status2 | Log10 (IU/mL) (range) | VC | Log10 (IU/mL) (range) | VC | |
| Pat #1 | Und | Positive | Negative | NA | NA | 4.40 ± 0.13 (4.20-4.48) | 0.03 |
| Pat #2 | A | Positive | Negative | NA | NA | 4.60 ± 0.09 (4.56-4.66) | 0.02 |
| Pat #3 | E | Positive | Positive | 2.80 ± 0.29 (2.60-3.01) | 0.10 | 4.46 ± 0.10 (4.39-4.53) | 0.02 |
| Pat #4 | A | Positive | Positive | 1.75 ± 1.20 (1.30-2.95) | 0.69 | 3.53 ± 0.14 (3.44-3.63) | 0.04 |
| Pat #5 | A | Positive | Positive | 3.25 ± 1.30 (2.13-4.35) | 0.40 | 4.87 ± 0.06 (4.86-4.93) | 0.01 |
| Pat #6 | D | Positive | Fluctuating | 2.32 ± 0.70 (1.00-3.42) | 0.30 | 4.52 ± 0.27 (4.01-4.78) | 0.06 |
| Pat #7 | E | Positive | Fluctuating | 1.36 ± 0.45 (1.00-2.48) | 0.33 | 3.94 ± 0.10 (3.80-4.12) | 0.03 |
| Pat #8 | D | Positive | Fluctuating | 1.65 ± 0.92 (1.00-2.30) | 0.56 | 4.64 ± 0.07 (4.59-4.69) | 0.02 |
| Pat #9 | A | Positive | Fluctuating | 1.62 ± 0.88 (1.00-2.48) | 0.54 | 4.17 ± 0.68 (3.68-4.64) | 0.16 |
| Pat #10 | D | Positive | Positive | 3.17 ± 0.56 (2.22-4.08) | 0.18 | 3.99 ± 0.19 (3.64-4.13) | 0.05 |
| Pat #11 | A | Positive | Negative | NA | NA | 4.55 ± 0.07 (4.48-4.63) | 0.02 |
| Pat #12 | D | Negative | Fluctuating | 3.22 ± 1.40 (1.00-4.99) | 0.43 | 4.45 ± 0.09 (4.30-4.58) | 0.02 |
| Pat #13 | A | Positive | Negative | NA | NA | 3.85 ± 0.17 (3.73-3.97) | 0.04 |
| Pat #14 | D | Positive | Fluctuating | 2.11 ± 0.73 (1.00-2.93) | 0.35 | 3.75 ± 0.10 (3.68-3.82) | 0.03 |
| Pat #15 | D | Positive | Positive | 2.76 ± 0.95 (1.97-4.76) | 0.34 | 3.55 ± 0.20 (3.20-3.73) | 0.06 |
| Pat #16 | E | Positive | Positive | 2.36 ± 0.10 (2.30-2.48) | 0.04 | 4.28 ± 0.10 (4.21-4.35) | 0.02 |
1
Genotyping results obtained by the combined use of LiPA and PCR/Sequencing techniques (see material and methods);
2
Evolution of HBV-DNA during follow-up. Fluctuating is defined as a patient with alternating positive and negative samples. HBV: Hepatitis B virus; VC: Variation coefficient; NA: Not applicable; Und: Undetermined genotype because of HBV-DNA negativity.