Table 1.
Experimental data of TCs and their pharmacokinetics values (adapted from www.drugbank.ca).
| Compounds | LogP | LogS | % Enteric absorption | % Serum protein binding | Renal clearance (mL/min) | Half-Life (hours) |
|---|---|---|---|---|---|---|
| Oxytetracycline | −1.3 | −3.14 | 58 | 30 | 90 | 10 |
| Tetracycline | −0.3 | −3.12 | 80 | 60 | 65 | 9 |
| Doxycycline | −0.2 | −2.87 | 93 | 85 | 16 | 15 |
| Demeclocycline | 0.2 | −2.52 | 66 | 75 | 31 | 13 |
| Chlorotetracycline | - | - | 30 | 55 | 35 | 6 |
| Meclocycline | - | - | - | - | - | - |
| Minocycline | 0.5 | - | 95 | 90 | 10 | 20 |
| Rolitetracycline | - | - | - | - | - | - |
| Tigecycline | 0.8 | - | - | 90 | - | 32 |
| Doxorububicine | −0.5 | - | - | 70 | - | 55 |