Table 2.

Results of the experimental infections.

Strain		Treatment regimen	Mean bacterial lung concentration (log CFU/g thigh)	Mortality (n)
Ab1	Clinical isolate	Untreated control	10.468	3/3
		Meropenem 20 mg /kg/8 h	10.250	1/3
		Meropenem 100 mg/kg/12 h	7.992	1/3
		Meropenem 400 mg/kg/8 h	8.480	0/3
Ab1h	Heterogeneous subpopulation	Untreated control	10.079	0/3
		Meropenem 20 mg /kg/8 h	10.010	0/3
		Meropenem 100 mg/kg/12 h	7.599	0/3
		Meropenem 400 mg/kg/8 h	6.135	0/3
Ab2	Clinical isolate	Untreated control	10.568	3/3
		Meropenem 20 mg/kg/8 h	10.450	2/3
		Meropenem 100 mg/kg/12 h	10.508	0/3
		Meropenem 400 mg/kg/8 h	7.393	0/3
Ab2h	Heterogeneous subpopulation	Untreated control	10.560	0/3
		Meropenem 20 mg /kg/8 h	10.450	0/3
		Meropenem 100 mg/kg/12 h	10.508	0/3
		Meropenem 400 mg/kg/8 h	7.393	0/3
Ab3	Clinical isolate	Untreated control	10.370	3/3
		Meropenem 20 mg/kg/8 h	10.250	2/3
		Meropenem 100 mg/kg/12 h	10.032	0/3
		Meropenem 400 mg/kg/8 h	8.100	0/3
Ab3h	Heterogeneous subpopulation	Untreated control	10.365	3/3
		Meropenem 20 mg /kg/8 h	10.125	0/3
		Meropenem 100 mg/kg/12 h	10.032	1/3
		Meropenem 400 mg/kg/8 h	8.124	0/3
Ab4	Clinical isolate	Untreated control	10.280	3/3
		Meropenem 20 mg/kg/8 h	10.145	1/3
		Meropenem 100 mg/kg/12 h	10.055	0/3
		Meropenem 400 mg/kg/8 h	7.950	0/3
Ab4h	Heterogeneous subpopulation	Untreated control	10.412	3/3
		Meropenem 20 mg /kg/8 h	10.275	1/3
		Meropenem 100 mg/kg/12 h	10.032	0/3
		Meropenem 400 mg/kg/8 h	8.116	0/3
Ab5	Clinical isolate	Untreated control	10.350	3/3
		Meropenem 20 mg/kg/8 h	10.150	2/3
		Meropenem 100mg/kg/12 h	10.035	1/3
		Meropenem 400 mg/kg/8 h	8.066	0/3
Ab5h	Heterogeneous subpopulation	Untreated control	10.128	0/3
		Meropenem 20 mg /kg/8 h	10.078	0/3
		Meropenem 100 mg/kg/12 h	10.032	0/3
		Meropenem 400 mg/kg/8 h	8.299	0/3
E. coli ATCC 25922		Untreated control	9.077	0/3
		Meropenem 20 mg/kg/8 h	8.015	0/3
		Meropenem 100 mg/kg/12 h	7.979	0/3
		Meropenem 400 mg/kg/8 h	2.015	0/3