Figure 1.

OprM structure with reported mutagenesis studies (a) the point of insertion of the malarial epitope performed by Wong [50] are presented in balls of different colors from red to green following the functional consequence on resistance. Red: protein not expressed or with resistance comparable to the OprM-inactivated strain; green: protein as active as the wild type (wtOprM); (b and c) two different views of OprM structure with mutations and deletions reported in [51] (same colour code as in (a)) and deletion studied in [50,52] that lead to important functional modifications when compared with wtOprM (colored in magenta).