Figure 1.
Structures of natural and semi-synthetic glycopeptide antibiotics (GPAs). Vancomycin and teicoplanin are natural products. In the case of teicoplanin, the clinically used antibiotic is a mixture of five lipoglycopeptide molecules differing in the length (C10-C11) and branching of the fatty acid tail, whose main component, the one reported in the figure, bears the 8-methylnonanoic (iso-C10:0) acid and is named T-A2-2. Oritavancin and telavancin are semi-synthetic second generation GPAs belonging to the vancomycin family. Dalbavancin is the semi-synthetic derivative of the teicoplanin-like A40926.