Table 1.
Antibiotics approved since 2000.
| Year approved | Drug name | Chemical structure | Class | Bacterial profile | Special features |
|---|---|---|---|---|---|
| 2000 | Linezolid |  |
oxazolidinone | G+ | MRSA |
| 2001 | Telithromycin |  |
Macrolide (ketolide) | G+/some G− | Safety concerns |
| 2002 | Biapenem |  |
carbapenem | G+, G− | Broad spectrum, including many β-lactamase producers |
| 2002 | Ertapenem |  |
carbapenem | G+, G− | Broad spectrum, including many β-lactamase producers |
| 2002 | Prulifloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2002 | Pazufloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2002 | Balofloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2003 | Daptomycin |  |
lipopeptide | G+ | MRSA, VRE |
| 2004 | Gemifloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2005 | Doripenem |  |
carbapenem | G+, G− | Broad spectrum, including many β-lactamase producers |
| 2005 | Tigecycline |  |
tetracycline (glycylglycine) | G+, G− | Broad spectrum |
| 2007 | Retapamulin |  |
pleuromutilin | G+ | MRSA |
| 2007 | Garenoxacin |  |
Quinolone | G+, G− | Broad spectrum, |
| 2008 | Ceftobiprole medocaril |  |
cephalosporin | G+, G− | Broad spectrum, MRSA |
| 2008 | Sitafloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2009 | Tebipenem pivoxil |  |
carbapenem | G+, G− | Broad spectrum, including many β-lactamase producers |
| 2009 | Telavancin |  |
glycopeptide | G+ | MRSA |
| 2009 | Antofloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2009 | Besifloxacin |  |
fluoroquinolone | G+, G− | Broad spectrum |
| 2010 | Ceftaroline fosaminyl |  |
cephalosporin | G+, G− | Broad spectrum |
| 2011 | Fidaxomycin |  |
macrocycle | G+ | C.difficile |
| 2012 | Bedaquiline |  |
diarylquinoline | acid-fast bacteria | Mycobacterium tuberculosis |