Table 1. Patient- and Transplantation-Characteristics.
Variable | Total Study Group | |
---|---|---|
Year of Transplant | 1995-1999 | 16 (13%) |
2000-2006 | 40 (32%) | |
2007-2013 | 68 (55%) | |
Age of Patients | < 50 | 41 (33%) |
50-60 | 47 (38%) | |
>60 | 36 (29%) | |
Median (range) (IQR) | 55 (18-72), (47-62) | |
Patient Gender | Male | 83 (67%) |
KPS | <90 | 25 (21%) |
90/100 | 97 (80%) | |
Recipient CMV Serostatus | Negative | 57 (46%) |
Positive | 67 (54%) | |
Donor Type | RD/URD Match | 67 (54%) |
RD/URD MM | 8 (7%) | |
UCB 5+6/6 | 24 (19%) | |
UCB 4/6 | 25 (20%) | |
Conditioning | MAC | 47 (38%) |
RIC: w/ ATG | 52 (42%) | |
RIC: w/o ATG | 25 (20%) | |
GvHD Prophylaxis | CSA/MMF | 75 (61%) |
CSA containing | 31 (25%) | |
Other | 18 (15%) | |
Diagnosis | MDS-NOS | 24 (19%) |
MDS - RA | 5 (4%) | |
MDS - RAEB-1 | 34 (27%) | |
MDS - RAEB-2 | 30 (24%) | |
MDS - RARS | 4 (3%) | |
MDS - RCMD | 21 (17%) | |
RCMD - RS | 6 (5%) | |
Months from Diagnosis to Transplant: | Median (range), (IQR) | 6 (1-371), (4-13) |
Therapy-related MDS | No | 94 (77%) |
Yes | 28 (23%) | |
Blast at alloHCT | <=2% | 74 (60%) |
>2-<5% | 33 (27%) | |
5-10% | 17 (14%) |
Abbreviations: AlloHCT, allogeneic hematopoietic cell transplantation; CMV, cytomegalovirus; CSA, cyclosporine; GVHD, graft-versus-host disease; IPSS, International Prognostic Scoring System; R-IPSS, International Prognostic Scoring System-revised; KPS, Karnofsky performance status; MAC, myeloablative conditioning; MDS, myelodysplastic syndrome; MDS-U, MDS- unclassifiable; MRD, matched related donor; MMRD, mismatched related donor; MTX, methotrexate; RIC, reduced intensity conditioning; MMF, mycophenolate mofetil; MDS, myelodysplastic syndrome; NOS, not otherwise specified; RA, refractory anemia; RAEB, refractory anemia with excess blasts; RARS, refractory anemia with ringed sideroblasts; RD, related donor; RCMD, refractory cytopenias with multilineage dysplasia; RCMD/RS, RCMD with ringed sideroblasts; UCB, umbilical cord blood; URD, unrelated donor; WHO, World Health Organization