Table 4. The effects of cytogenetic scoring system groupings on alloHCT outcomes adjusted for donor type, conditioning and baseline Karnofsky.
| Time | Cytogenetic scoring systems | Cytogenetic Risk Score | NRM at 3 years | P-value | Relapse at 3 years | P-value | DFS at 3 years | P-value | OS at 3 years | P-value |
|---|---|---|---|---|---|---|---|---|---|---|
| AT DIAGNOSIS | IPSS | Good | 22%(8-36%) | 0.01 | 21%(8-34%) | 0.28 | 59%(43-73%) | <0.01 | 67%(51-83%) | <0.01 |
| Intermediate | 55%(45-65%) | 35%(17-53%) | 11%(1-23%) | 16%(4-30%) | ||||||
| Poor | 42%(28-56%) | 26%(15-37%) | 32%(20-44%) | 37%(24-50%) | ||||||
| R-IPSS | Very Good/Good | 21%(7-35%) | <0.01 | 23%(9-37%) | 0.02 | 57%(41-73%) | <0.01 | 66%(50-82%) | <0.01 | |
| Intermediate | 59%(38-80%) | 36%(17-55%) | 8%(1-19%) | 19%(3-35%) | ||||||
| Poor | 47%(29-65%) | 10%(1-21%) | 41%(24-58%) | 44%(26-62%) | ||||||
| Very Poor | 35%(16-54%) | 39%(22-56%) | 24%(7-41%) | 27%(11-44%) | ||||||
| TSCG | Standard | 36%(24-48%) | 0.29 | 28%(17-39%) | 0.98 | 37%(25-49%) | 0.36 | 44%(31-57%) | 0.28 | |
| Adverse | 44%(31-57%) | 26%(15-37%) | 31%(19-43%) | 36%(24-48%) | ||||||
| MK | No | 40%(29-51%) | 0.96 | 23%(14-32%) | 0.02 | 39%(28-50%) | 0.01 | 47%(36-59%) | 0.02 | |
| Yes | 35%(19-51%) | 38%(23-43%) | 27%(12-42%) | 29%(14-44%) | ||||||
| AT ALLOHCT | IPSS | Good | 27%(13-41%) | 0.19 | 27%(14-40%) | 0.86 | 47%(32-62%) | 0.09 | 57%(42-72%) | <0.01 |
| Intermediate | 56%(36-76%) | 29%(12-46%) | 19%(4-34%) | 22%(6-38%) | ||||||
| Poor | 43%(29-57%) | 25%(13-37%) | 32%(19-45%) | 36%(22-50%) | ||||||
| R-IPSS | Very Good/Good | 27%(13-31%) | 0.23 | 29%(16-52%) | 0.84 | 45%(30-60%) | 0.02 | 56%(41-71%) | <0.01 | |
| Intermediate | 59%(39-79%) | 27%(10-44%) | 18%(3-33%) | 24%(6-42%) | ||||||
| Poor | 37%(17-57%) | 18%(2-34%) | 44%(23-65%) | 49%(29-69%) | ||||||
| Very Poor | 46%(26-66%) | 31%(14-47%) | 24%(6-42%) | 23%(6-40%) | ||||||
| TSCG | Standard | 40%(28-52%) | 0.51 | 27%(17-37%) | 0.73 | 36%(24-48%) | 0.27 | 42%(31-54%)53%) | 0.34 | |
| Adverse | 41%(27-54%) | 28%(16-40%) | 32%(19-45%) | 38%(24-52%) | ||||||
| MK | No | 41%(31-51%) | 0.85 | 25%(16-34%) | 0.17 | 36%(26-46%) | 0.10 | 43%(33-53%) | 0.08 | |
| Yes | 39%(21-60%) | 34%(18-50%) | 28%(12-44%) | 31%(14-48%) |