Skip to main content
. 2004 Jul 20;2(9):e275. doi: 10.1371/journal.pbio.0020275

Figure 4. Selective Pressures on APOBEC1, APOBEC2, and APOBEC3E.

Figure 4

Sliding window analysis (250-bp window; 50-bp slide) was performed on three APOBEC genes. Although APOBEC1 demonstrates purifying selection when the whole gene is analyzed (Table 1), the sliding window analysis of a human–orangutan comparison reveals a window (aa 1–100) in the first active site (dark gray bar), which shows evidence of positive selection (p < 0.01). Sliding window analysis of APOBEC2, which is also evolving under purifying selection (Table 1), does not show any windows where ω is greater than one. APOBEC3E, which gives the strongest signal for positive selection (Table 1), has ω greater than one for almost all windows. (Note that ω is not plotted where Ks = 0).

DOI:10.1371/journal.pbio.0020275.g004