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. Author manuscript; available in PMC: 2016 Mar 14.
Published in final edited form as: Informatics (MDPI). 2014 May 30;1(1):72–99. doi: 10.3390/informatics1010072

Figure 1.

Figure 1

(a) Illustrated within each circle “Inflammation,” “Disease State,” and “Pathogen” are markers that can be utilized as molecular targets in the diagnosis of infection. The identification of general inflammatory markers, depicted in the “Inflammation” circle, indicate the inflammation surrounding an infection, but increased specificity of diagnosis can be gained by focusing on targets associated with a disease state or pathogen. Endocarditis and Staphylococcus aureus are depicted here as representative of a disease state and associated pathogen of interest, respectively, with current pre-clinical (*) or clinical (#) applications noted.