Table 1.
Case-case comparison of demographic and tumor characteristics of early onset basal cell carcinoma (BCC) compared to later onset BCC.
| Variable | Early onset (≤50 years old) N (%) |
Late onset (> 50 years old) N (%) |
OR (95% CI)1 | |
|---|---|---|---|---|
| Gender | male | 259 (38.4) | 540 (59.7) | 1.0 (ref) |
| female | 415 (61.6) | 364 (40.3) | 2.2 (1.7–2.7) | |
| Histologic subtype2 | nonaggressive BCC | 463 (92.4) | 467 (97.9) | 1.0 (ref) |
| aggressive BCC | 38 (7.6) | 10 (2.1) | 3.9 (1.9–8.0) | |
| Solar elastosis | low/moderate | 42 (40.4) | 65 (25.0) | 1.0 (ref) |
| severe | 62 (59.6) | 195 (75.0) | 0.5 (0.3–0.8) | |
| Anatomic Site | trunk | 33 (5.0) | 110 (12.5) | 1.0 (ref) |
| lower limbs | 5 (0.8) | 14 (1.6) | 1.1 (0.4–3.3) | |
| upper limbs | 6 (0.9) | 20 (2.3) | 1.2 (0.4–3.2) | |
| head or neck | 611 (93.3) | 734 (83.6) | 2.8 (1.9–4.2) |
1
Odd ratios and 95% confidence intervals were estimated by logistic regression and adjusted by study phase and gender (male, female).
2
Tumor morphology was reviewed by a single pathologist in phase 2 and phase 3 of the study on the 978 subjects whose tumor material was available. The aggressive histology types are 8092.1/3 8092.2/3 8092.3/3.