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. 2016 Mar 10;6:22894. doi: 10.1038/srep22894

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(a) Comparison of amino acid sequence in HMG-CoA reductase between Homo sapiens (HsHMGR) and S. aureus (SaMvaA). Residues corresponding to M77, A335, and C366 of S. aureus MvaA are indicated in red letters. (b) A complex of Homo sapiens HMG-CoA reductase and HMG-CoA (PDB ID: 1DQ9)²⁷. Red: the M555, Q815, or M854; Green: amino acid residues locating within 4Å from the residues indicated in red; Blue: HMG-CoA. (c) A complex of Homo sapiens HMG-CoA reductase and HMG, CoA, NADP⁺ (PDB ID: 1DQA)²⁷. Red: the M555, Q815, or M854; Green: amino acid residues locating within 4Å from the residues indicated in red; Blue: HMG, Yellow: NADP⁺, Purple: CoA.