Figure 5.

Nuclear factor erythroid 2-related factor 2 (Nrf2)-KO mice exhibit increased systemic inflammation following hemorrhagic shock (HS). Plasma from wild-type (WT) and Nrf2-KO mice was collected 2 h after HS. (A) Interleukin (IL)-6, (B) IL-1β and (C) tumor necrosis factor (TNF)-α plasma levels were determined by ELISA. The results represent mean cytokine levels shown as the means ± SEM (n≥4 samples per group). N.D., not detected. ^*p<0.05 vs. sham-operated group (sham), ^†p<0.05 vs. WT mice.