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. Author manuscript; available in PMC: 2016 Mar 14.
Published in final edited form as: J Mater Chem B. 2015 Sep 30;4(9):1672–1685. doi: 10.1039/C5TB01754H

Fig. 6.

Fig. 6

Combinations of microparticle-loaded adjuvants up-regulate dendritic cell activation markers to varying degrees. Microparticle formulations were organized left to right by the level of expression/production of markers from highest to lowest (mean ± standard error) for (a) CD86, (b) MHC-II (c) CCR7 (d) IL-12 (e) IL-10, where the x-axis represents each of the 216 unique formulations. Brackets identify formulations eliciting the highest 10% responses, and are listed in (f). Highlighted are adjuvant combinations with particularly high expression of more than one marker, with the condition consisting of CpG:MPLA:poly I:C at a ratio of 1c:2m:2p generating the highest pro-inflammatory state of DCs indicated by MHC-IIHiCD86HiIL-12HiCCR7HiIL-10Lo. Key: c – CpG; m – MPLA; p – poly I:C; 0 – no particle; 1–62 particles; 2 – 125 particles; 3 – 250 particles; 4 – 500 particles; 5 – 1000 particles.