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(A) C21orf2 was significantly knocked-down by both siRNAs (siRNA-1 and 2). (B-D) mRNA expression of chondrocyte differentiation marker genes. The expression of the marker genes decreased when C21orf2 was knocked-down. *: P< 0.05, **: P< 0.01, ***: P< 0.001; versus control by t-test. n = 3.
