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. 2016 Mar 14;11(3):e0150462. doi: 10.1371/journal.pone.0150462

Fig 1. Peptide nanoparticle-mediated siRNA can efficiently enter intact mouse oocytes.

Fig 1

(A) Fluorescence comparison between the three different groups. Left, control oocytes without any treatment; middle, oocytes incubated with FITC-conjugated control siRNA only; right, oocytes incubated with peptide nanoparticle-encapsulated FITC-conjugated control siRNA. Corresponding bright field images of live oocytes are shown in the upper panel. GV oocytes were treated and then cultured till MII. (B) Quantification of FITC fluorescence of the three groups in A. Numbers in or above columns are numbers of oocytes measured. A significant comparison (p<0.05) is indicated with an asterisk (*). Scale bar, 20 μm.