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. 2016 Feb 22;113(10):2708–2713. doi: 10.1073/pnas.1523236113

Fig. 1.

Fig. 1.

BAT transplantation reverses PCOS BAT activity. BAT activity was assessed at the end of the experiment (3 wk after tissue transplantation) by using PET-CT. BAT transplantation could significantly increase endogenous BAT activity in the DHEA+BAT group compared with the DHEA+sham or DHEA+Mus groups (A). Yellow triangle indicates the anatomical site of the interscapular BAT. The activity of brown adipose tissue, expressed as the standard uptake values (SUVs), dramatically decreased in the DHEA+sham and DHEA+Mus groups compared with the control and BAT transplantation groups (B). Furthermore, BAT transplantation could significantly increase BAT-specific marker gene expression (C) and OXPHOS protein expression (D), as well as UCP1 expression (E), compared with the DHEA+sham or DHEA+Mus groups. Data were analyzed by one-way ANOVA with Tukey’s post hoc test. n = 8–10 per group. Different lowercase letters indicate significant differences among groups (One-way ANOVA, with Tukey’s post hoc test, P < 0.05).