Fig. S2.
Related to Fig. 1. Presynaptic origin of 5-HT2A receptor-mediated potentiation of NMDA EPSCs. (A and B) Cumulative fraction of all interevent intervals of AMPA receptor-mediated mEPSCs measured before and after bath application of DOI in low (A) or high (B) magnesium in ACSF. In A, AMPA receptor-mediated mEPSCs were also measured for 5 min after DOI washout (n = 7). (C) Cumulative distribution of all interevent intervals of AMPA receptor-mediated mEPSCs detected for a 5-min baseline period, a 5-min period following bath application of D,L-AP5 (100 μM, in low magnesium ACSF) and a 5-min period following further addition of DOI (1 μM, n = 7) to the bath. ***P < 0.001 vs. baseline; ###P < 0.001 vs. DOI condition; n.s., not significant, Student’s t test or one-way ANOVA followed by Newman–Keuls test.