Fig. S4.

Cocaine pretreatment alters temporally specific D1, but not D2, MSN activity. (A) Group data showing that peak D1 amplitude is increased in cocaine pretreated animals during both extinction and reinstatement compared with saline-pretreated controls [two-way ANOVA; F (1, 26) = 6.44, P < 0.05, n = 6, 9]. (B) Group data showing that D2 signaling is unchanged between cocaine and saline pretreated animals during both extinction and reinstatement. *P < 0.05. All data are presented as mean ± SEM.