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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Jan 13;1862(4):763–777. doi: 10.1016/j.bbadis.2016.01.011

Fig. 2.

Fig. 2

Ca2+ mishandling in HF. Alterations in RyR2, SERCA2a, NCX, Na+/K+ ATPase (NKA) and TRPC channels lead to impaired Ca2+ and Na+ handling, which negatively impacts the contractibility of failing cardiomyocytes. NKA: Na+/K+ ATPase.