Figure 4.

A genome-wide comparison of medaka and zebrafish linkage groups with their human orthologous genes. Although there were three exceptions, most LGs in both species showed pair-wise combinations with similar color patterns. Genes in red indicate orthologous gene pairs in LGs sharing a putative ancestral proto-chromosome. Green and yellow boxes indicate sets of orthologous gene pairs observed in putative orthologous regions in medaka and zebrafish. Zebrafish mapping information and orthologous relationships to human genes were mainly obtained from Woods et al. (2000), Barbazuk et al. (2000), and LocusLink (http://www.ncbi.nlm.nih.gov/LocusLink/; revised November 24, 2003).