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. Author manuscript; available in PMC: 2016 Mar 14.
Published in final edited form as: Chem Res Toxicol. 2015 Apr 16;28(5):1036–1044. doi: 10.1021/acs.chemrestox.5b00060

Figure 2.

Figure 2

Survival plots for mice pretreated with HI-6 or HI-6 plus human AChE mutant Y337A/F338A 5 min prior to exposure to 10 x LD50 of soman. Doses in pre-treatment were 1 mg/kg AChE mutant and 110 mg/kg HI-6. All mice received HI-6 (110 mg/kg) in atropine (10 mg/kg) 1 min after soman exposure. Experiment utilized four mice in each group.