Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Mar 15;27(6):979–989. doi: 10.1091/mbc.E15-07-0503

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Evans et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

“ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

PMC Copyright notice

FIGURE 6: — The YHRD mutations decrease evoked neurotransmission in cultured hippocampal neurons. (A) Representative evoked EPSC traces recorded from WT, syt-1 KO, and KO neurons expressing WT, YHRD, 3×, and 3×-YHRD constructs. (B and C) Bar graphs of evoked EPSC amplitude (pA; B) and total charge (pC; C). The number of neurons in each group are indicated inside the bars. (D) Normalized cumulative total charge transfer, averaged for each group; a double exponential function was used to fit the data. (E) Representative evoked EPSCs recorded from KO neurons expressing WT or YHRD in the presence of the indicated extracellular Ca²⁺ concentration, [Ca²⁺]_ex. There were 10–20 neurons analyzed per condition. All data represent mean ± SEM; *, p < 0.05; **, p < 0.01.