Table 3.
Pathologic response
| Primary tumor (N=37 eligible resected patients) | Value |
|---|---|
| RT desmoplasia | |
| No | 26 (70%) |
| Yes | 11 (30%) |
| Tumor size | |
| Median | 2.9 cm |
| Range | 1.3–4.8 |
| Histologic grade | |
| Moderate differentiation | 17 (46%) |
| Poor differentiation | 20 (54%) |
| Perineural invasion | |
| No | 5 (14%) |
| Yes | 32 (86%) |
| Lymphovascular invasion | |
| No | 19 (51%) |
| Yes | 18 (49%) |
| Margin status | |
| Negative | 31 (84%) |
| Positive | 6 (16%) |
| Nodal Involvement | |
| No | 7 (19%) |
| Yes | 30 (81%) |
| Nodes: total assessed | |
| Median | 18 |
| Range | 6–37 |
| Nodes: number positive (among the 30 patients with nodal involvement) | |
| Median | 2 |
| Range | 1–12 |
| Sites of metastatic failure (n=35 patients with distant progression) | |
| Liver* | 20 (57%) |
| Lung* | 14 (40%) |
| Hilar and mediastinal adenopathy* | 1 (3%) |
| Supraclavicular area | 1 (3%) |
| Pleural effusion | 1 (3%) |
Abbreviation: RT = radiation therapy.
*
Two patients had simultaneous metastatic progression at 2 sites.