Skip to main content
. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Oncogene. 2015 Sep 14;35(17):2247–2265. doi: 10.1038/onc.2015.288

Figure 1. Expression of YAP protein and alterations of YAP-associated genes in Fallopian tube cancer (FTC) and ovarian high grade serous carcinoma (HGSC).

Figure 1

a) Quantitative data showing YAP immunosignal positivity (percentage of the YAP positive cell number relative to the total cell number) in normal, inflammatory (chronic tube inflammation, Inflam) and cancerous (tumor) Fallopian tube tissues determined by immunohistochemistry. b) Quantitative data showing YAP immunosignal intensity in normal, inflammatory (Inflam) and cancerous Fallopian tube tissues determined by immunohistochemistry. Each bar represents the mean ± SEM (n=5 for Normal, n=10 for Inflam, n=10 for tumor. *: P < 0.05, ***: P < 0.001. c) Quantitative data showing YAP immunosignal positivity in the ovarian normal tissues and ovarian HGSC. d) Quantitative data showing YAP immunosignal intensity in the ovarian normal tissues and ovarian HGSC. CTRL: normal ovarian tissues used as control; HGSC: ovarian high grade serous carcinoma tissues. Each bar represents the mean ± SEM (n=42 for CTRL, n=105 for HGSC). ***: P < 0.001. e) Alterations of YAP gene across the gynecological cancers. The cross cancer YAP gene alteration analyses was performed using online datasets and data mining tools (the cBioPortal for Cancer Genomics and the datasets from the TCGA research Network). f) Alterations of YAP, LATS1 and TEAD genes in the ovarian high grade serous carcinoma. Data sources and analysis tools are the same as in e). g) Correlation between overall survival and YAP/TEAD expression in the ovarian HGSC. Data were extracted from the TCGA datasets using the cBioPortal and uploaded to the GraphPad Prism 5 for statistical analysis. Total: Correlation between YAP/TEAD levels and overall survival in all ovarian HGSC cases (n=418); YAP/TEAD down: Correlation between YAP/TEAD expression levels and the overall survival in 19 cases of ovarian HGSC in which YAP/TEAD expression levels are lower and are out of the default Z score thresholds.