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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Oncogene. 2015 Sep 14;35(17):2247–2265. doi: 10.1038/onc.2015.288

Figure 5. YAP induces Fallopian tube high grade serous carcinoma.

Figure 5

a) Histology and molecular features of tumors-derived from FT194-YAPS127A cells. H-E: Representative image showing histology of FT194-YAPS127A tumors tissues stained with hematoxylin-eosin. Ki67: representative image showing expression of Ki67 protein in FT194-YAPS127A tumor tissues analyzed by immunohistochemistry. FT194-YAPS127A tumors also express high level of cytokeratin 7 (KRT7), nuclear TP53, PAX8 and WT1, but not cytokeratin 20 (KRT20) and PAX2. Scale bar: 20μm. b) Representative images showing that tumor tissues derived from FT194-YAP cells are negative for the Alcian blue PH2.5-Periodic acid (AB-PAS) staining. Left: colorectal epithelium was used as a positive control for AB-PAS staining. Right: tumor tissues derived from FT194-YAP cells were AB-PAS negatively stained. Scale bar: 25μm.