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. 2015 Oct 19;6(41):43508–43528. doi: 10.18632/oncotarget.6180

Figure 7. y-secretase inhibition by DBZ inhibits growth but does not induce leukemic cell death.

Figure 7

A., B. DBZ inhibits proliferation of leukemic cells. Inhibition rates of proliferation of Jurkat A. and CEM cells B. after treatment with DBZ for 72h at indicated concentrations are shown. EC50 is indicated. n = 3. Scale bar 50 μm. C., D. Colony formation of Jurkat C. and CEM cells D. after treatments with DBZ at indicated concentrations is shown. Scale bar 100 μm. One-Way ANOVA, Tukey, **p ≤ 0.01, ***p ≤ 0.001, n = 3. E., F. Apoptosis rate determined by Nicoletti assay of Jurkat E. and CEM cells F. after treatments with DBZ at indicated concentrations for 72h is shown. n = 3. G. Apoptosis rate determined by Annexin V/PI staining of Jurkat cells after treatments with DBZ at indicated concentrations for 24h, 48h, and 72h is shown. 24h and 48h: n = 2. 72h: n = 3. H. Apoptosis rate determined by PI exclusion of PDX leukemic cells with/without treatments with DBZ (48h) at indicated concentrations is shown.