Table 3. Stratified analyses of different biopsy schemes.

	n	Sample size*	Heterogeneity		MR/US fusion biopsy vs System biopsies
			Ph	I2, %	RR (95%CI)	p
Total	16	3013/3105	0.14	28	1.06 (1.01, 1.12)a	0.03a
					1.09 (1.01, 1.18)b	0.02b
Low MRI suspicion	4	253/554	0.05	63	0.36 (0.26, 0.49)	< 0.01
					0.36 (0.21, 0.63)	< 0.01
Moderate/High MRI suspicion	4	365/554	0.61	0	1.46 (1.28, 1.67)	< 0.01
					1.43 (1.27, 1.63)	< 0.01
Clinically significant PCa	10	2481/2583	0.46	0	1.19 (1.10, 1.29)	< 0.01
					1.19 (1.10, 1.28)	< 0.01
Clinically insignificant PCa	10	2395/2494	0.08	43	0.68 (0.59, 0.79)	< 0.01
					0.66 (0.51, 0.86)	< 0.01

CI = confidence interval; RD = risk difference.

P_h values for heterogeneity from Q-test.

^*MR/US fusion biopsy sample size/System biopsies sample size

^aFixed effect model was used when heterogeneity P_h >0.05.

^bRandom effect model was used when heterogeneity P_h <0.05.