Table 1. Baseline characteristics of nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy with or without concurrent chemotherapy.
The original unmatched cohort | The propensity-matched cohort | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
IMRT alone (N = 254) | IMRT+CC (N = 407) | P | Standardized difference | IMRT alone (N = 241) | IMRT+CC (N = 241) | P | Standardized difference | |||||
No. | % | No. | % | No. | % | No. | % | |||||
Age | 0.021 | 0.181 | 0.894 | 0.012 | ||||||||
Mean | 48.31 | 46.24 | 47.99 | 47.85 | ||||||||
SD | 12.30 | 10.49 | 12.22 | 10.31 | ||||||||
Median | 46.50 | 45.00 | 46.00 | 47.00 | ||||||||
Sex | 0.540 | 0.049 | 0.917 | 0.009 | ||||||||
Male | 189 | 74.4 | 294 | 72.2 | 179 | 74.3 | 180 | 74.7 | ||||
Female | 65 | 25.6 | 113 | 27.8 | 62 | 25.7 | 61 | 25.3 | ||||
Histology* | 0.501 | 0.055 | 0.611 | 0.046 | ||||||||
II | 8 | 3.1 | 17 | 4.2 | 7 | 2.9 | 9 | 3.7 | ||||
III | 246 | 96.9 | 390 | 95.8 | 234 | 97.1 | 232 | 96.3 | ||||
VCA-IgA† | 0.160 | 0.628 | ||||||||||
<80 | 69 | 27.2 | 89 | 21.9 | 0.123 | 61 | 25.3 | 59 | 24.5 | 0.019 | ||
80–320 | 94 | 37.0 | 145 | 35.6 | 0.029 | 90 | 37.3 | 82 | 34.0 | 0.069 | ||
≥320 | 91 | 35.8 | 173 | 42.5 | 0.137 | 90 | 37.3 | 100 | 41.5 | 0.085 | ||
EA-IgA† | 0.107 | 0.592 | ||||||||||
<10 | 111 | 43.7 | 147 | 36.1 | 0.155 | 102 | 42.3 | 97 | 40.2 | 0.042 | ||
10–40 | 80 | 31.5 | 134 | 32.9 | 0.031 | 78 | 32.4 | 73 | 30.3 | 0.045 | ||
≥40 | 63 | 24.8 | 126 | 31.0 | 0.138 | 61 | 25.3 | 71 | 29.5 | 0.093 | ||
T-stage | < 0.001 | 0.701 | ||||||||||
T1 | 74 | 29.1 | 96 | 23.6 | 0.126 | 73 | 30.3 | 69 | 28.6 | 0.036 | ||
T2 | 140 | 55.1 | 186 | 45.7 | 0.189 | 128 | 53.1 | 125 | 51.9 | 0.025 | ||
T3 | 40 | 15.7 | 125 | 30.7 | 0.360 | 40 | 16.6 | 47 | 19.5 | 0.076 | ||
N-stage | 0.503 | 0.053 | 0.296 | 0.095 | ||||||||
N0 | 104 | 40.9 | 156 | 38.3 | 92 | 38.2 | 81 | 33.6 | ||||
N1 | 150 | 59.1 | 251 | 61.7 | 149 | 61.8 | 160 | 66.4 | ||||
Clinical stage | < 0.001 | 0.360 | 0.407 | 0.075 | ||||||||
II | 214 | 84.3 | 282 | 69.3 | 201 | 83.4 | 194 | 80.5 | ||||
III | 40 | 15.7 | 125 | 30.7 | 40 | 16.6 | 47 | 19.5 |
Abbreviations: IMRT = intensity-modulated radiotherapy, CC = concurrent chemotherapy, SD = standard deviation, VCA = viral capsid antigen, EA = early antigen, IgA = immunoglobulin A
Based on the criteria of WHO histological type (1991): II - Differentiated non-keratinising carcinoma, III - Undifferentiated non-keratinising carcinoma
In accordance with the criteria adopted in previous studies