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. 2016 Mar 15;10:22. doi: 10.3389/fncom.2016.00022

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Copyright © 2016 Couto and Grill.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of inter-spike interval (ISI) histograms and ISI pair histograms for fibers exhibiting intrinsic bursting activity, regular firing, and irregular firing. (A) Transmembrane voltage in bursting, regular, and irregular firing model nerve fibers. (B) Histograms representing the probability of each ISI interval. (C) ISI pair maps illustrating the probability of an ISI pair. Larger circles represent higher probability. Bursting fibers (entropy 1.49 bits/spike) displayed peaks at short (intra-burst spikes) and at long (inter-burst spikes) ISIs; as compared to regular firing fibers (entropy 0 bits/spike) that displayed a single peak at the firing frequency in both the ISI histograms and the ISI pair histograms. Irregular fibers displayed very different firing patterns; in this example (entropy 2.8 bits/spike) the ISI histogram and ISI pair histograms are spread below 50 ms.