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. 2016 Mar 15;7:93. doi: 10.3389/fphys.2016.00093

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Copyright © 2016 Prathipati, Metreveli, Nandi, Tyagi and Mishra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abrogation of MMP9 improves cardiomyocytes calcium transients in diabetic Akita mice. (A) Fluorescence ratio of FURA-2 binding to calcium was recorded from myocytes isolated from WT, Akita, and DKO hearts. Cardiomyocytes were stimulated at 1 Hz and calcium ratio was measured during contraction/relaxation cycle. (B) Rate of calcium decay per second in WT, Akita, and DKO cardiomyocytes showing increased decay in Akita and restoration of decay in DKO. (C) Calcium released during contraction-relaxation cycle was decreased in Akita but normalized in DKO. Each bar represents mean ± SEM from 15 to 20 cardiomyocytes from each group. N = 4–7. ^*p < 0.05.