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. 2016 Mar 2;7(3):159–174. doi: 10.1007/s13238-016-0250-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Regulation of myeloid cell development and differentiation by Notch signaling. Notch signaling critically controls multiple steps of myeloid cell development and differentiation program including early myelopoiesis, development of certain DC population, osteoclast differentiation, and inflammatory macrophage polarization. Abbreviations: HSC, hematopoietic stem cell; GMP, granulocyte-macrophage progenitor; MDP, macrophage-dendritic cell progenitor; CDP, common dendritic cell precursor; OCP, osteoclast precursor; pDC, plasmacytoid dendritic cells