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. 2016 Feb 16;7(3):175–186. doi: 10.1007/s13238-016-0247-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Single cell transcriptome analysis revealed maturation-related genes. (A) Expression of genes positively (green cluster) and negatively (magenta cluster) correlated to dimension 1 of electrophysiological parameters (Correlation > 0.4 and P < 0.05, Student correlation P-values) in 20 single neurons. (B) GO analyses of genes negatively correlated to dimension 1 (magenta cluster, 350 genes), enriched in mature neurons. Length of bars indicated the significance (−log10 transferred P-value, Fisher exact test). (C) Hub-gene network of the magenta gene cluster. (D) GO analyses of genes positively correlated with dimension 1 (green cluster, 94 genes), enriched in immature neurons. Length of bars indicated the significance (−log10 transferred P-value, Fisher exact test). (E) Hub-gene network of the green gene cluster